Prekallikrein (Fletcher Factor) (Last Updated - 2/27/2005)

-aka. Fletcher Factor
-along with high molecular weight kininogen (HMWK) & kaolin catalyzes the activation of Factor XII to XIIa to initiate the intrinsic pathway
-this step produces not only Factor XIIa but also kallikrein

-click here to view an image of the clotting cascade

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References:

Goodman & Gilman's: The Pharmacologic Basis Of Therapeutics - 10th Edition - 2001. Chapter 55.